LIFEMany stars have made appearances on Two and a Half MenGuest stars Elvis Costello (left) and Sean Penn joined Charlie Sheen during the second-season premiere, showing 'Two and a Half Men could attract big-name guests.WARNER BROS., WARNER BROTHERS TELEVISION INCGuest star Morgan Fairchild (left) joins 'Men' star Charlie Sheen during a Season 4 episode.GREG GAYNE, WARNER BROS.Charlie (Charlie Sheen), left, tries to set up brother Alan (Jon Cryer) with beautiful neighbor Danielle (Brooke Shields) in a fourth-season episode.MONTY BRINTON, CBSAlan (Jon Cryer), left, hangs out with his mother's new boyfriend Teddy (guest star Robert Wagner) in the fourth-season finale.GREG GAYNE, WARNER BROS.Janeane Garofalo (left) guest stars as a new love interest for Alan (Jon Cryer) in a fifth-season episode.Cliff Lipson, CBS'Men' mother Evelyn (Holland Taylor), left, talks with her 'almost' daughter-in-law (Jenny McCarthy) in a Season 5 episode. McCarthy guest-starred on numerous occasions.Michael Ansell, WARNER BROS.Musical star Eddie Van Halen, left, and star Charlie Sheen talk during the Season 7 premiere episode.Greg Gayne, WARNER BROS.Comedy legend Carl Reiner, right, joins series regular Holland Taylor during a scene in a Season 7 Christmas episode.Greg Gayne, WARNER BROS.Alan (Jon Cryer), center, worries he is being stalked by Lyndsey's ex-husband (guest star and 'Breakfast Club'-ber Judd Nelson), left, in a Season 8 episode. Courtney Thorne-Smith, who plays Lyndsey, is at the right.Greg Gayne, WARNER BROS.Guest star Georgia Engel, left joins 'Men' star Holland Taylor in a Season 9 episode where Lyndsey's and Alan's mothers meet.Darren Michaels, WARNER BROS.Alan (Jon Cryer), left, recovering from a minor heart attack, sees Charlie's ghost (Oscar winner Kathy Bates) in a ninth-season episode. Bates won an Emmy for the role.Darren Michaels, Warner Bros. Television Entertainment'Seinfeld's' Jason Alexander left, plays a cardiologist speaking to heart attack survivor Alan (Jon Cryer) in the series 200th episode in 2012.Darren Michaels, WARNER BROS.Guest stars Ryan Stiles, Patton Oswalt and Willie Garson join star Ashton Kutcher during Season 10.Monty Brinton, CBSRyan Stiles, standing, appears with star Ashton Kutcher in a Season 10 episode, one of 'The Drew Carey Show' alum's numerous guest appearances.Michael Yarish, WARNER BROS.Musical star Miley Cyrus, seen on left with ÔMenÕ star Ashton Kutcher, appeared in two 10th-season episodes, playing the love interest of AlanÕs son, Jake.Greg Gayne, CBSMarilu Henner, left, and Hilary Duff play grandmother and granddaughter in a scene with star Ashton Kutcher in a 10th-season episode.Cliff Lipson, CBSAlan (Jon Cryer), left, talks to Lyndsey's boyfriend (D.B. Sweeney) and Lyndsey (Courtney Thorne-Smith) in a Season 11 episode.Sonja Flemming, CBSA behind-the-scenes shot captures guest star Jeff Probst in a somewhat compromising position during a Season 11 episode in which the 'Survivor' host played himselfCliff Lipson, CBSAlan (Jon Cryer) left, dates a woman (guest star Paula Marshall) who tells him that she used to be a man in a Season 11 episode.Darren Michaels, WARNER BROS.Guest star Odette Annable ('House, M.D.'), left, guest stars in a Season 11 episode with star Ashton Kutcher.Michael Yarish, WARNER BROS.'Happy Days' Marion Ross, left, guest starred in a Season 11 episode, appearing here with star Jon Cryer.Michael Yarish, WARNER BROS.Carl Reiner, with hand raised, returns as multi-millionaire Marty Pepper in a guest-star-studded 11th-season bachelor party scene that features Tim Conway, far left, Steve Lawrence, star Jon Cryer, Garry Marshall, second from right, and star Ashton Kutcher (far right).Sonja Flemming, CBSStar Ashton Kutcher, left, and comedy legend Tim Conway chat behind the scenes during filming of a Season 11 episode.Sonja Flemming, CBSGuest stars Kimberly Williams-Paisley, left, and Brad Paisley and recurring star Courtney Thorne-Smith, on the sofa, appear in the 11th-season finale with stars Jon Cryer, second from right, and Ashton Kutcher.Michael Ansell, WARNER BROS.Mimi Rogers, left, guest stars with star Ashton Kutcher in a final-season episode.Michael Yarish, WARNER BROS.Featured Weekly Ad