Prurigo Nodularis

Prurigo nodularis is a skin condition characterized by hard, itchy bumps that develop on the skin. These bumps, or nodules, can be round or oval in shape and range in size from a few millimeters to several centimeters in diameter. They are often red or brown in color and may be covered with small, dark scales.

Prurigo nodularis is a chronic condition, which means it tends to persist over a long period of time and may recur. It is more common in people with certain underlying conditions, such as eczema or kidney disease, but it can also occur in people with no underlying health problems. It is more common in women than in men, and tends to affect people between the ages of 20 and 60.

The cause of prurigo nodularis is not fully understood, but it is thought to be related to an abnormal immune system response to certain triggers, such as insect bites, allergies, or infections. It may also be related to underlying conditions that affect the skin, such as eczema or kidney disease.


Prurigo nodularis can be difficult to treat, and may require a combination of approaches. Options may include:

  • Topical medications: These may include creams or ointments that contain corticosteroids or other anti-inflammatory agents. These can help to reduce inflammation and itching.

  • Oral medications: These may include antihistamines, which can help to reduce itching, or immunosuppressants, which can help to suppress the immune system and reduce inflammation.

  • Light therapy: This may involve the use of ultraviolet light to help improve the appearance of the skin.

  • Biologics: These are newer medications that work by targeting specific immune system pathways. They may be used for people who do not respond to other treatments.

  • Surgical removal: This may be an option for large or painful nodules that have not responded to other treatments. However, there is a risk that the nodules will return after surgery.

It is important to work closely with your dermatology provider to determine the best treatment approach for prurigo nodularis. In some cases, the condition may resolve on its own over time, but it is important to follow a treatment plan to help manage symptoms and prevent the condition from worsening.


Prurigo nodularis can be a frustrating and distressing condition, but with proper treatment, it can be managed. If you are concerned about a skin condition or think you may have prurigo nodularis, it is important to speak with a dermatologist or other healthcare provider. They can help to determine the cause of your symptoms and develop a treatment plan to help improve your skin health.